Matrix Metalloproteinases-Modulating the Tumor Microenvironment
نویسندگان
چکیده
منابع مشابه
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis. Recent technological developments have markedly advanced our understanding of MMPs as modul...
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Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly influenced by the surrounding microenvironment of the tumor. Therefore, the ability to change these surroundings represents an important property through which tumor cells are able to acquire specific functions necessary for tumor growth and dissemination. Matrix metalloproteinases (MMPs) constitute key play...
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Pathologically activated fibroblasts have been shown to play a role in fibrotic disorders and cancer, but the molecular mechanisms regulating their emergence are still poorly characterized. A recent study demonstrates that unleashing metalloproteinase activity in fibroblasts is sufficient for the acquisition of an activated pro-tumorigenic phenotype. Stromal cells and extracellular matrix (ECM)...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2015
ISSN: 2157-2518
DOI: 10.4172/2157-2518.1000225